Molecular Processes Implicated in Human Age-Related Nuclear Cataract
نویسندگان
چکیده
منابع مشابه
Gene expression profiling in human age-related nuclear cataract.
PURPOSE To identify genes that are differentially expressed in age-related nuclear cataracts compared to transparent human lenses. METHODS Total RNA was extracted from pools of central 5 mm capsulorrhexis epithelial samples microdissected at surgery from eyes with nuclear cataract or from age-matched transparent lenses (post-mortem). mRNA levels in the two samples were compared by hybridizati...
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PURPOSE To investigate associations between enzyme activity of glutathione reductase (GR) with and without added flavin adenine dinucleotide (FAD), glutathione peroxidase (GPX), and 6-phosphogluconic dehydrogenase (6PGDH) in the lens epithelium collected at surgery, and some nutritional and biochemical variables determined in the same individuals during the Italian-American Case-Control Study o...
متن کاملDecreased expression of ribosomal proteins in human age-related cataract.
PURPOSE To identify lens epithelial genes with altered expression levels in age-related human cataract. METHODS Epithelia from age-related cataracts and from normal lenses were microdissected and RNA was extracted. RNAs were compared for gene expression differences by RT-PCR differential display. Transcripts exhibiting altered levels of gene expression were cloned and identified by sequencing...
متن کاملFrailty and age-related cataract.
OBJECTIVE To determine whether there is an association between age-related cataract and frailty that persists after controlling for visual acuity (VA) and comorbid conditions. DESIGN Cross-sectional. PARTICIPANTS Two thousand three hundred seventy Beaver Dam Eye Study cohort members at 10-year (third) examination with cataract information. Ninety-nine percent of the population was Caucasian...
متن کاملHuman age-related cataract and lens epithelial cell death.
PURPOSE To evaluate the importance of lens epithelial cell death in age-related cataract. To determine whether the large percentage of terminal deoxynucleotidyl transferase (TdT)-mediated dUTP nick-end labeling (TUNEL)-positive lens epithelial cells previously reported in human capsulotomy specimens results from apoptosis or necrosis. METHODS Capsulotomy specimens from patients who had underg...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2019
ISSN: 1552-5783
DOI: 10.1167/iovs.19-27535